Lithium modulation of the human inositol monophosphatase 2 (IMPA2) promoter.

  title={Lithium modulation of the human inositol monophosphatase 2 (IMPA2) promoter.},
  author={Ratnam S Seelan and Latha K Parthasarathy and Ranga N. Parthasarathy},
  journal={Biochemical and biophysical research communications},
  volume={324 4},
The inositol-signaling pathway is a therapeutic target for lithium in the treatment of bipolar disorder. Inositol monophosphatases (IMPases) play a key role in inositol signaling. Lithium's ability to inhibit IMPase 1 is well known, but its effect on IMPase 2 or on the transcriptional regulation of these genes has not been studied. Here, we report the identification and characterization of the minimal promoter of IMPA2 (encoding IMPase 2) in HeLa (epithelial) and SK-N-AS (neuronal) cells. IMPA2… CONTINUE READING