Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons

  title={Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons},
  author={Kathrin Scheuch and Markus H{\"o}ltje and Holger Budde and Marion Lautenschlager and Andreas Heinz and Gudrun Ahnert-Hilger and Josef Priller},
  journal={Brain Research},
Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression
Preliminary findings are consistent with the hypothesis that these mood stabilizers enhance 5-HT1A receptor expression in BD, which may underscore an important component of these agents’ mechanism of action.
Tryptophan hydroxylase-2: an emerging therapeutic target for stress disorders.
Effect Of Therapeutic Lithium Carbonate Doses On Rat Brain Content Of Mood Regulating Neurotransmitters
The actions reveal that lithium has a remarkable effect on brain neuronal function which probably postulates an interesting impact of lithium treatment in shifting amino acids and needed minerals in direction of improving the mood, through neurotransmission homeostasis.
Bipolar Disorders and Lithium: Pharmacokinetics, Pharmacodynamics, Therapeutic Effects and Indications of Lithium: Review of Articles
  • Medicine
  • 2016
Lithium is a mood stabilizer which is approved for use in acute and maintenance mania. It is the first medications approved for the treatment of bipolar disorders. The drug has narrow therapeutic
Lithium reverses mechanical allodynia through a mu opioid-dependent mechanism
Evidence is provided that lithium induces a long-lasting analgesia in neuropathic mice presumably through elevated brain levels of beta-endorphin and the activation of MORs.


Chronic lithium administration enhances serotonin release in the lateral hypothalamus but not in the hippocampus in rats. A microdialysis study
The effect of lithium on the PFH could be related to the improvement of the autonomic and cyclic symptoms of patients with manic depressive disorders undergoing lithium therapy.
Short- and Long-Term Lithium Administration: Effects on the Brain's Serotonergic Biosynthetic Systems
Conversion of tryptophan to serotonin in nerve endings becomes a joint function of the maintained increased uptake of tryaptophan and a decreased level of tryPTophan hydroxylase activity in nerve Ending by 10 days.
A unique central tryptophan hydroxylase isoform.
Effects of lithium chloride on parameters biosynthetic capacity for 5-hydroxytryptamin in rat brain.
  • S. KnappA. Mandell
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1975
The sequence of events that the authors observed after lithium treatment is consistent with receptor-mediated neuronal feedback regulation of tryptophan hydroxylase activity after stimulation of tryPTophan uptake and conversion of 5-HT.
Effect of subchronic lithium treatment on citalopram‐induced increases in extracellular concentrations of serotonin in the medial prefrontal cortex
Lithium augmentation of the antidepressant effect of SSRI is mediated by the additional increases in extracellular 5‐HT concentrations following the co‐administrations of lithium and SSRI.
Lithium in Tricyclic-Resistant Depression Correlation of Increased Brain 5-HT Function with Clinical Outcome
Lithium may increase brain 5-HT function in tricyclic-resistant depression but there is only limited support for the hypothesis that changes in brain 5 -HT function are involved in the antidepressant effect of this treatment combination.
Clinical studies of 5-HT function using I.V. l-Tryptophan
Rapid response to the addition of lithium in iprindole-resistant unipolar depression: a pilot study.
: The authors administered lithium carbonate, 900 mg/day, in an open study to seven patients with a major unipolar depression refractory to 3-week treatment with iprindole, 90 mg/day, a tricyclic