Lithium ion transport and affective disorders within families of bipolar patients. Identification of a major gene locus.

@article{Dorus1983LithiumIT,
  title={Lithium ion transport and affective disorders within families of bipolar patients. Identification of a major gene locus.},
  author={Elizabeth Dorus and Nancy J. Cox and Robert D. Gibbons and R. A. Shaughnessy and G. N. Pandey and C. Robert Cloninger},
  journal={Archives of general psychiatry},
  year={1983},
  volume={40 5},
  pages={545-52}
}
We have identified a genetic polymorphism in which one allele results in elevated RBC lithium ion ratios and also contributes to vulnerability to some forms of affective disorders. Interindividual variability in the lithium ion ratio (the ratio of the RBC to the plasma lithium ion concentration) is determined by variability in a lithium ion ratio (the ratio of the RBC to the plasma lithium ion concentration) is determined by variability in a lithium-sodium ion counterflow mechanism. Segregation… CONTINUE READING