Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells.

@article{Mao2001LithiumIC,
  title={Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells.},
  author={Catherine D Mao and P. Hoang and Paul E. Dicorleto},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 28},
  pages={26180-8}
}
Lithium affects development of various organisms and cell fate through the inhibition of glycogen synthase kinase-3 beta and induction of the Wnt/beta-catenin signaling pathway. In this study, we investigated the effects of lithium on primary bovine aortic endothelial cells (BAEC). Lithium treatment of BAEC induced beta-catenin stabilization but failed to activate the transcriptional activity of the beta-catenin/T-cell factor complex. Lithium caused a sustained G(2)/M cell cycle arrest without… CONTINUE READING