Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy.

@article{Heiseke2009LithiumIC,
  title={Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy.},
  author={Andreas Heiseke and Yasmine Aguib and Constanze Riemer and Michael M. Baier and Hermann M Sch{\"a}tzl},
  journal={Journal of neurochemistry},
  year={2009},
  volume={109 1},
  pages={25-34}
}
Lithium is used for several decades to treat manic-depressive illness (bipolar affective disorder). Recently, it was found that lithium induces autophagy, thereby promoting the clearance of mutant huntingtin and alpha-synucleins in experimental systems. We show here for the first time that lithium significantly reduces the amount of pathological prion protein (PrP(Sc)) in prion-infected neuronal and non-neuronal cultured cells by inducing autophagy. Treatment of prion-infected cells with 3… CONTINUE READING