Lithium induces c-Ret expression in mouse inner medullary collecting duct cells.

  title={Lithium induces c-Ret expression in mouse inner medullary collecting duct cells.},
  author={Nobuhiko Kojima and Hiroshi Saito and Masaki Nishikawa and Shunsuke Yuri and Oak Don Jo and Phuong-Chi Pham and Naomi Yanagawa and Norimoto Yanagawa},
  journal={Cellular signalling},
  volume={23 2},
We found in our present study that lithium (Li(+)) induced the expression of endogenous c-Ret, a tyrosine kinase receptor, in murine inner medullary collecting duct (mIMCD-3) cells. Delineation of the promoter region required for the effect of Li(+) identified a positive regulatory element within 180bp upstream of the transcription initiation site. This region contained three putative GC-rich Sp1 binding sites found to be essential for c-Ret induction by Li(+). The effect of Li(+) was mediated… CONTINUE READING


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