Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.

@article{Hashimoto2002LithiumIB,
  title={Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity.},
  author={Ryota Hashimoto and Nobuyuki Takei and Kazuhiro Shimazu and Lori Christ and Bai Lu and D. -M. Chuang},
  journal={Neuropharmacology},
  year={2002},
  volume={43 7},
  pages={1173-9}
}
Mechanisms underlying the therapeutic effects of lithium for bipolar mood disorder remain poorly understood. Recent studies demonstrate that lithium has neuroprotective actions against a variety of insults in vitro and in vivo. This study was undertaken to investigate the role of the brain-derived neurotrophic factor (BDNF)/TrkB signaling pathway in mediating neuroprotection of lithium against glutamate excitotoxicity in cortical neurons. Pretreatment with either lithium or BDNF protected rat… CONTINUE READING
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