Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.

@article{Alsady2018LithiumIA,
  title={Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.},
  author={Mohammad Alsady and Theun de Groot and Marleen L. A. Kortenoeven and Claudia Carmone and Kim Neijman and Melissa Bekkenkamp-Grovenstein and Udo F. H. Engelke and Ron A Wevers and Ruben Baumgarten and Ron Korstanje and Peter Meinardus T. Deen},
  journal={American journal of physiology. Renal physiology},
  year={2018},
  volume={314 2},
  pages={F230-F239}
}
Lithium, given to bipolar disorder patients, causes nephrogenic diabetes insipidus (Li-NDI), a urinary-concentrating defect. Li-NDI occurs due to downregulation of principal cell AQP2 expression, which coincides with principal cell proliferation. The metabolic effect of lithium on principal cells, however, is unknown and investigated here. In earlier studies, we showed that the carbonic anhydrase (CA) inhibitor acetazolamide attenuated Li-induced downregulation in mouse-collecting duct (mpkCCD… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
0 Citations
53 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Similar Papers

Loading similar papers…