Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride.

@article{Bedford2008LithiuminducedND,
  title={Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride.},
  author={Jennifer J. Bedford and Susan Weggery and Gaye Ellis and Fiona J. Mcdonald and Peter R. Joyce and John P. Leader and Ronald J. Walker},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2008},
  volume={3 5},
  pages={
          1324-31
        }
}
BACKGROUND AND OBJECTIVES Polyuria, polydipsia, and nephrogenic diabetes insipidus have been associated with use of psychotropic medications, especially lithium. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The impact of psychotropic medications on urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion was investigated after overnight fluid deprivation, and over 6 h after 40 microg of desmopressin (dDAVP), in patients on lithium (n = 45), compared with those on alternate… CONTINUE READING

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