Lithium in the treatment of aggression in mentally handicapped patients. A double-blind trial.

@article{Craft1987LithiumIT,
  title={Lithium in the treatment of aggression in mentally handicapped patients. A double-blind trial.},
  author={Michael Craft and Ihab A. Ismail and Diane Krishnamurti and Jayne Mathews and Allistair Regan and Rajiv Seth and Patricia North},
  journal={The British journal of psychiatry : the journal of mental science},
  year={1987},
  volume={150},
  pages={
          685-9
        }
}
In a double-blind trial lasting 4 months in 42 mentally handicapped patients, the effect of lithium on aggression was assessed in comparison with placebo. In the lithium-treated group, 73% of patients showed a reduction in aggression during treatment. There were significant differences in mean weekly aggression scores and in the frequency of aggressive episodes between the lithium and placebo groups. Side-effects were noted in 36% of the lithium group (and 20% of the placebo group), but were… CONTINUE READING