Lithium in Paediatric Patients with Bipolar Disorder: Implications for Selection of Dosage Regimens via Population Pharmacokinetics/Pharmacodynamics.

@article{Landersdorfer2017LithiumIP,
  title={Lithium in Paediatric Patients with Bipolar Disorder: Implications for Selection of Dosage Regimens via Population Pharmacokinetics/Pharmacodynamics.},
  author={Cornelia B. Landersdorfer and Robert L. Findling and Jean A. Frazier and Vivian Kafantaris and Carl M. J. Kirkpatrick},
  journal={Clinical pharmacokinetics},
  year={2017},
  volume={56 1},
  pages={
          77-90
        }
}
BACKGROUND Lithium is a well-established treatment for bipolar I disorder in adults. However, there is a paucity of information on its pharmacokinetics/pharmacodynamics in children and adolescents. We aimed to develop the first lithium dosage regimens based on population pharmacokinetics/pharmacodynamics for paediatric patients. METHODS Lithium concentrations, Young Mania Rating Scale (YMRS) and Clinical Global Impressions-Improvement (CGI-I) scores over 24 weeks were available from 61… CONTINUE READING
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