Lithium does not attenuate the effects of D-amphetamine in healthy volunteers.

@article{Silverstone1998LithiumDN,
  title={Lithium does not attenuate the effects of D-amphetamine in healthy volunteers.},
  author={Peter H. Silverstone and A Pukhovsky and Susan Rotzinger},
  journal={Psychiatry research},
  year={1998},
  volume={79 3},
  pages={219-26}
}
It has previously been suggested that an acute dose of 20 mg D-amphetamine can be a good model of mania. In the present study we attempted to validate this model by determining if subacute administration of lithium (for 7 days) would attenuate the effects of 20 mg D-amphetamine in human volunteers. Sixteen healthy volunteers were enrolled in this double-blind, placebo-controlled study. Subjects received either oral lithium at night for 7 nights (1200 mg) (n = 10) or matching placebo (n = 6). On… CONTINUE READING

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