Lithium diisopropylamide-mediated ortholithiations: lithium chloride catalysis.

Abstract

Ortholithiations of a range of arenes mediated by lithium diisopropylamide (LDA) in THF at -78 degrees C reveal substantial accelerations by as little as 0.5 mol % of LiCl (relative to LDA). Substrate dependencies suggest a specific range of reactivity within which the LiCl catalysis is optimal. Standard protocols with unpurified commercial samples of n… (More)
DOI: 10.1021/jo802713y

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