Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease.

@article{Assadi2010LithiumCR,
  title={Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease.},
  author={Mitra Assadi and Christopher G Janson and D Wang and Olga Goldfarb and Neeti Suri and Larissa L Bilaniuk and Paola Leone},
  journal={European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society},
  year={2010},
  volume={14 4},
  pages={354-9}
}
Our group has previously reported the first clinical application of lithium in a child affected by Canavan disease. In this study, we aimed to assess the effects of lithium on N-acetyl aspartate (NAA) as well as other end points in a larger cohort. Six patients with clinical, laboratory and genetic confirmation of Canavan disease were recruited and underwent treatment with lithium. The battery of safety and efficacy testing performed before and after sixty days of treatment included Gross Motor… CONTINUE READING
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