Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patients.

@article{Silverstone2009LithiumAV,
  title={Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patients.},
  author={Peter H. Silverstone and Brent M McGrath},
  journal={International review of psychiatry},
  year={2009},
  volume={21 4},
  pages={414-23}
}
Over 25 years ago it was suggested that the mechanism by which lithium was clinically effective may be due to a stabilizing effect on the phosphoinositol second messenger system (PI-cycle), which has multiple effects within cells. It was proposed that lithium, which is an inhibitor of one of the key enzymes in the PI-cycle, acted to lower myo-inositol concentrations; termed the 'inositol-depletion hypothesis'. Initial animal evidence supported this hypothesis, and also suggested that it was… CONTINUE READING
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Lithium-induced modulation of cerebral inositol phosphate metabolism in the rat: A multinuclear magnetic resonance study in vivo

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