Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patients

  title={Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patients},
  author={Peter H. Silverstone and Brent M McGrath},
  journal={International Review of Psychiatry},
  pages={414 - 423}
Over 25 years ago it was suggested that the mechanism by which lithium was clinically effective may be due to a stabilizing effect on the phosphoinositol second messenger system (PI-cycle), which has multiple effects within cells. It was proposed that lithium, which is an inhibitor of one of the key enzymes in the PI-cycle, acted to lower myo-inositol concentrations; termed the ‘inositol-depletion hypothesis’. Initial animal evidence supported this hypothesis, and also suggested that it was… 

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