Neurobehavioral effects of lithium in the rat: Investigation of the effect/concentration relationships and the contribution of the poisoning pattern.
1. Adult male Sprague Dawley rats were given lithium as a dietary supplement, or a control diet. 2. A single seven hour test of exploratory behavior was carried out after one week of chronic drug exposure . 3. The structure of exploration was significantly altered by the diet, with experimental animals exploring less intensely and with increased spacing of activity episodes. 4. These findings may represent a useful preclinical analog of some typically observed therapeutic effects of lithium.