Lithium and the other mood stabilizers effective in bipolar disorder target the rat brain arachidonic acid cascade.

@article{Rapoport2014LithiumAT,
  title={Lithium and the other mood stabilizers effective in bipolar disorder target the rat brain arachidonic acid cascade.},
  author={Stanley I. Rapoport},
  journal={ACS chemical neuroscience},
  year={2014},
  volume={5 6},
  pages={459-67}
}
This Review evaluates the arachidonic acid (AA, 20:4n-6) cascade hypothesis for the actions of lithium and other FDA-approved mood stabilizers in bipolar disorder (BD). The hypothesis is based on evidence in unanesthetized rats that chronically administered lithium, carbamazepine, valproate, or lamotrigine each downregulated brain AA metabolism, and it is consistent with reported upregulated AA cascade markers in post-mortem BD brain. In the rats, each mood stabilizer reduced AA turnover in… CONTINUE READING
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