Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania.

@article{CechinelRecco2012LithiumAT,
  title={Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania.},
  author={Kelen Cechinel-Recco and Samira S Valvassori and Roger Bitencourt Varela and Wilson R. Resende and Camila Orlandi Arent and Marcelo Fontana Vitto and Gabrielle da Luz and Claudio Teodoro de Souza and Jo{\~a}o Quevedo},
  journal={Journal of psychopharmacology},
  year={2012},
  volume={26 12},
  pages={1594-604}
}
Lithium (Li) is the main mood stabilizer and acts on multiple biochemical targets, leading to neuronal plasticity. Several clinical studies have shown that tamoxifen (TMX) - a protein kinase C (PKC) inhibitor - has been effective in treating acute mania. The present study aims to evaluate the effects of TMX on biochemical targets of Li, such as glycogen synthase kinase-3β (GSK-3β), PKC, PKA, CREB, BDNF and NGF, in the brain of rats subjected to an animal model of mania induced by d-amphetamine… CONTINUE READING