Lithium and nephrotoxicity: Unravelling the complex pathophysiological threads of the lightest metal

@article{Davis2018LithiumAN,
  title={Lithium and nephrotoxicity: Unravelling the complex pathophysiological threads of the lightest metal},
  author={Justin Davis and Michael Desmond and Michael Berk},
  journal={Nephrology},
  year={2018},
  volume={23}
}
While lithium remains the most efficacious treatment for bipolar disorder, it can cause significant nephrotoxicity. The molecular mechanisms behind both this process and the development of nephrogenic diabetes insipidus still remain to be fully elucidated but appear to involve alterations in glycogen synthase kinase 3 signalling, G2 cell cycle progression arrest, alterations in inositol and prostaglandin signalling pathways, and dysregulated trafficking and transcription of aquaporin 2 water… 
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