Lithium and Cell Physiology

  title={Lithium and Cell Physiology},
  author={Ricardo O. Bach and Vincent S. Gallicchio},
  booktitle={Springer New York},
Lithium and Cell Physiology explores the role of lithium in a wide range of physiologic contexts. The contributions reflect the most recent advances in our understanding of the biochemical, pharmacological, and clinical applications of this metal ion. The book discusses how lithium modulates cells of the immune system, stimulates granulopoiesis, and influences the course of viral infections. The effect of lithium on the skin, as well as on inositol phosphate metabolism, cell growth, magnesium… Expand
Li+ Transport Properties in Perfused Neuronal Cells by 7Li NMR Spectroscopy
Lithium salts have been clinically used, for more than forty years, in the treatment of manic-depression or bipolar disease, as well as in other psychiatric and non-psychiatric disorders, such asExpand
Lithium homeostasis in Xenopus oocytes: implications for the study of signal transduction.
The Xenopus oocyte might not be a suitable model for evaluating the effects of lithium on signal transduction pathways because of the unknown contribution of the sequestered pool on predicting relevant physiological effects. Expand
Lithium effects on stem cells - advances in stem cell application in clinical medicine
Evidence showing Li as important in neurogenesis, neuronal repair, as well as protecting neurons from neurotoxicity is shown, appears sufficient to label Li as an essential element with the recommended RDA for a 70 kg adult of 1 mg/day. Expand
myo-Inositol metabolism in plants
Here, an attempt is made to enlist new interest in all facets of myo-inositol metabolism and its place in plant biology. Expand
Applications of 7Li NMR in biomedicine
The applications of (7)Li NMR spectroscopy and imaging in biology and experimental medicine have been progressing steadily. The interest derives primarily from the clinical use of Li salts to treatExpand
How does lithium mediate its therapeutic effects
This paper aims to provide a history of psychiatry in the Czech Republic and some of the departments involved in the development of psychiatric medicine and its applications in the treatment of psychiatric disorders. Expand
Is lithium biologically an important or toxic element to living organisms? An overview
It is suggested that Li could be biologically important to living organism depending upon its concentration/exposure and molecular understanding of its accumulation and mode of action, which might have future implications for Li’s long-term effects on living organisms. Expand
Appendix A14.1 Older Findings in Manic-Depressive Illness To supplement the discussion of the neurobiology of bipolar disorder in Chapter 14, here we provide a summary of older but important biological findings in manic-depressive illness
  • 2007
To supplement the discussion of the neurobiology of bipolar disorder in Chapter 14, here we provide a summary of older but important biological findings in manic-depressive illness that have not beenExpand
Competition between lithium and magnesium ions for the G-protein transducin in the guanosine 5'-diphosphate bound conformation.
Evidence is found of Li(+)/Mg(2+) competition in G(t)-containing preparations that competes with Mg2+ for the Mm2+ binding sites on guanine-nucleotide binding proteins (G-proteins). Expand
Alterations in the metabolism of choline-containing phospholipids by lithium and carbachol in SH-SY5Y neuroblastoma cells
The data suggest that carbamoylcholine does not stimulate phosphatidylcholine degradation, whereas LiCl can significantly affect its metabolism and may affect signal transduction via second messengers in human neuroblastoma cells. Expand


Erythrocyte concentrations of the lithium ion: clinical correlates and mechanisms of action.
It appears that some bipolar patients accumulate more Li+ in their red cells than either unipolar depressives or normal controls, and the measurement of red cell concentrations of Li+, in addition to the usual plasma measurement, can be used as an indicator of patient compliance. Expand
Repression of a lithium pump as a consequence of lithium ingestion by manic-depressive subjects
It is postulate that repression of the lithium pump results from systemically available factors which alter membrane structure, and suggests that if such changes also occur in the central nervous system, they may provide insight into one means by which lithium produces its psychotropic affects. Expand
Coupling of lithium to sodium transport in human red cells
The experiments described here were designed to clarify the mechanisms of this seemingly ouabain-insensitive ‘active’ transport of lithium ions in human red cells. Expand
Biology of the lithium ion.
  • G. Pandey, J. Davis
  • Biology, Chemistry
  • Advances in experimental medicine and biology
  • 1980
Although lithium is one of the most effective drugs used in the treatment of manic-depressive illness, its mode of action remains unclear. Expand
It is concluded that therapeutic concentrations of lithium produce an irreversible inhibition of the choline transport system in human erythrocytes. Expand
7Li NMR study of normal human erythrocytes
Abstract The biological action of lithium is of great interest because of the therapeutic efficacy of the cation in manic-depressive illness. To investigate possible molecular interactions ofExpand
Lithium treatment strongly inhibits choline transport in human erythrocytes.
The administration of lithium to patients significantly reduces the transport of choline; during the first 6 weeks of treatment the influx is about half the normal rate, later it falls to around 10% and this inhibition of ch Caroline transport is not dependent on the presence of lithium in the incubation medium. Expand
Lithium and viruses.
  • R. O. Bach
  • Chemistry, Medicine
  • Medical hypotheses
  • 1987
The activity of the lithium ion against DNA type viruses is explained by its competition with magnesium ions, which displaces the magnesium as the enzymatic cofactor, thereby halting viral replication. Expand
Lithium ion entry through the sodium channel of cultured mouse neuroblastoma cells: a biochemical study.
Lithium ion entry at low concentrations (1 to 5 mM) into an electrically active adrenergic clone of mouse neuroblastoma cells was stimulated by veratridine; and this stimulation was blocked byExpand
Lithium incorporation in the fibroblasts of manic-depressives
The lithium ratio is probably not a good measure for differentiating the two populations, and a fibroblast lithium ratio calculated from 1-hr lithium incorporation studies correlated highly with an in vitro RBC lithium ratio in medication-free controls. Expand