Lithium Therapy Improves Neurological Function and Hippocampal Dendritic Arborization in a Spinocerebellar Ataxia Type 1 Mouse Model

@article{Watase2007LithiumTI,
  title={Lithium Therapy Improves Neurological Function and Hippocampal Dendritic Arborization in a Spinocerebellar Ataxia Type 1 Mouse Model},
  author={Kei Watase and Jennifer R. Gatchel and Yaling Sun and Effat Emamian and Richard Atkinson and Ronald Richman and Hidehiro Mizusawa and Harry T. Orr and Chad A. Shaw and Huda Y. Zoghbi},
  journal={PLoS Medicine},
  year={2007},
  volume={4},
  pages={743 - 755}
}
BACKGROUND Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited neurodegenerative disorder characterized by progressive motor and cognitive dysfunction. Caused by an expanded polyglutamine tract in ataxin 1 (ATXN1), SCA1 pathogenesis involves a multifactorial process that likely begins with misfolding of ATXN1, which has functional consequences on its interactions, leading to transcriptional dysregulation. Because lithium has been shown to exert neuroprotective effects in a variety of… CONTINUE READING
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