Lithium Impacts on the Amplitude and Period of the Molecular Circadian Clockwork

@inproceedings{Li2012LithiumIO,
  title={Lithium Impacts on the Amplitude and Period of the Molecular Circadian Clockwork},
  author={Jian Li and Wei-qun Lu and Stephen Beesley and Andrew S. I. Loudon and Qing-Jun Meng},
  booktitle={PloS one},
  year={2012}
}
  • Jian Li, Wei-qun Lu, +2 authors Qing-Jun Meng
  • Published in PloS one 2012
  • Biology, Medicine
  • Lithium salt has been widely used in treatment of Bipolar Disorder, a mental disturbance associated with circadian rhythm disruptions. Lithium mildly but consistently lengthens circadian period of behavioural rhythms in multiple organisms. To systematically address the impacts of lithium on circadian pacemaking and the underlying mechanisms, we measured locomotor activity in mice in vivo following chronic lithium treatment, and also tracked clock protein dynamics (PER2::Luciferase) in vitro in… CONTINUE READING

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