Lithium: Updated Human Knowledge Using an Evidence-Based Approach

@article{Grandjean2009LithiumUH,
  title={Lithium: Updated Human Knowledge Using an Evidence-Based Approach},
  author={Etienne Marc Grandjean and Jean-Michel Aubry},
  journal={CNS Drugs},
  year={2009},
  volume={23},
  pages={331-349}
}
After a single dose, lithium, usually given as carbonate, reaches a peak plasma concentration at 1.0–2.0 hours for standard-release dosage forms, and 4–5 hours for sustained-release forms. Its bioavailability is 80–100%, its total clearance 10–40 mL/min and its elimination half-life is 18–36 hours. Use of the sustained-release formulation results in 30–50% reductions in peak plasma concentrations without major changes in the area under the plasma concentration curve.Lithium distribution to the… 
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