Lithium: Bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium

@article{Mrmol2008LithiumBD,
  title={Lithium: Bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium},
  author={Frederic M{\'a}rmol},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2008},
  volume={32},
  pages={1761-1771}
}
  • F. Mármol
  • Published 12 December 2008
  • Psychology, Biology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
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It has yet to be determined which of these is the principal factor responsible for lithium's therapeutic action, while at the same time the possibility cannot be totally ruled out that its precise mechanism of action is still to be discovered.
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Recent insights into lithium's actions are reviewed, leading to the strategic development of improved therapeutics for the treatment of bipolar disorder and its intracellular downstream targets including adenylate cyclase, the phosphoinositol cascade, arachidonic acid metabolism, and effects on neurotrophic cascade.
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