Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells.

@article{Sibelius1996ListeriolysinIA,
  title={Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells.},
  author={Ulf Sibelius and Frank Rose and Trinad Chakraborty and Ayub Darji and J{\"u}rgen Wehland and Siegfried Weiss and Werner Seeger and Friedrich Grimminger},
  journal={Infection and immunity},
  year={1996},
  volume={64 2},
  pages={
          674-6
        }
}
The impact of Listeria monocytogenes listeriolysin O (LLO) secretion on phosphoinositide metabolism and mediator (platelet-activating factor and prostaglandin I2) generation was investigated in human umbilical vein endothelial cells. Wild-type L. monocytogenes, purified LLO, and an L. innocua strain engineered to secrete LLO all elicited a strong response, whereas mutant strains defective in LLO production were ineffective. Thus, human umbilical vein endothelial cell stimulation by listeriae is… CONTINUE READING

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