Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity.

@article{Crimmins2008ListeriaMM,
  title={Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity.},
  author={Gregory T. Crimmins and Anat A Herskovits and Kai Rehder and Kelsey E. Sivick and Peter M. Lauer and Thomas W Dubensky and Daniel A Portnoy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 29},
  pages={10191-6}
}
To gain insight into the interaction of intracellular pathogens with host innate immune pathways, we performed an unbiased genetic screen of Listeria monocytogenes mutants that induced an enhanced or diminished host innate immune response. Here, we show that the major facilitator superfamily of bacterial multidrug resistance transporters (MDRs) controlled the magnitude of a host cytosolic surveillance pathway, leading to the production of several cytokines, including type I IFN. Mutations… CONTINUE READING
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