Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes.

@article{Burke2014ListeriaMI,
  title={Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes.},
  author={Thomas P. Burke and Anastasia Loukitcheva and Jason Zemansky and Richard Wheeler and Ivo G Boneca and Daniel A Portnoy},
  journal={Journal of bacteriology},
  year={2014},
  volume={196 21},
  pages={3756-67}
}
Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that is highly resistant to lysozyme, a ubiquitous enzyme of the innate immune system that degrades cell wall peptidoglycan. Two peptidoglycan-modifying enzymes, PgdA and OatA, confer lysozyme resistance on L. monocytogenes; however, these enzymes are also conserved among lysozyme-sensitive nonpathogens. We sought to identify additional factors responsible for lysozyme resistance in L. monocytogenes. A forward genetic… CONTINUE READING