Listeria monocytogenes infection-dependent transfer of exogenously added DNA to fibroblast COS-1 cells

@article{Stritzker2004ListeriaMI,
  title={Listeria monocytogenes infection-dependent transfer of exogenously added DNA to fibroblast COS-1 cells},
  author={Jochen Stritzker and W. Goebel},
  journal={Molecular Genetics and Genomics},
  year={2004},
  volume={272},
  pages={497-503}
}
The addition of double-stranded circular or linear DNA encoding EGFP (the Enhanced Green Fluorescent Protein) to a Listeria -containing infection medium resulted in up to 8.6% COS-1 cells expressing the reporter protein. The transfer of naked DNA into host cells upon infection by Listeria was found to be dependent on the ability of the bacteria to synthesize internalins and listeriolysin. Since no binding of DNA to the bacterial cells was detected, DNA uptake seems to be the consequence of the… CONTINUE READING
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