Listeria monocytogenes as novel carrier system for the development of live vaccines.

@article{Schoen2008ListeriaMA,
  title={Listeria monocytogenes as novel carrier system for the development of live vaccines.},
  author={Christoph Schoen and Daniela I M Loeffler and Alexa Frentzen and S. A. L. Pilgrim and W. Goebel and Jochen Stritzker},
  journal={International journal of medical microbiology : IJMM},
  year={2008},
  volume={298 1-2},
  pages={
          45-58
        }
}
Listeria monocytogenes is a facultative intracellular bacterium that enters a variety of non-professional mammalian cells by triggered phagocytosis ("zipper mechanism") and replicates in the cytosol of the infected host cells. Therefore, it is a promising vaccine vector for the presentation of passenger antigens to the MHC class II and especially class I pathways. Here, we review recent progress made in our laboratory on the development of novel attenuated L. monocytogenes carrier strains for… CONTINUE READING
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