Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence.

@article{Rea2005ListeriaMP,
  title={Listeria monocytogenes PerR mutants display a small-colony phenotype, increased sensitivity to hydrogen peroxide, and significantly reduced murine virulence.},
  author={Rosemarie B. Rea and C. Ray Hill and Cormac G. M. Gahan},
  journal={Applied and environmental microbiology},
  year={2005},
  volume={71 12},
  pages={8314-22}
}
Deletion of perR in Listeria monocytogenes results in a small-colony phenotype (DeltaperRsm) that is slow growing and exhibits increased sensitivity to H2O2. At a relatively high frequency, large-colony variants (DeltaperRlg) arise, which are more resistant to H2O2 than the wild-type and ultimately dominate the culture. Transcriptional analysis revealed that the kat gene (catalase) is up-regulated in both types of mutants and that the highest level is apparent in DeltaperRsm mutants… CONTINUE READING

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References

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Expression analysis of a highly adherent and cytotoxic small-colony variant of Pseudomonas aeruginosa isolated from a lung of a patient with cystic fibrosis

F. von Götz, S. Häussler, +8 authors I. Steinmetz
J. Bacteriol • 2004

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