Listeria monocytogenes — from saprophyte to intracellular pathogen

  title={Listeria monocytogenes — from saprophyte to intracellular pathogen},
  author={Nancy E. Freitag and Gary C. Port and Maurine D. Miner},
  journal={Nature Reviews Microbiology},
Listeria monocytogenes is a bacterium that lives in the soil as a saprophyte but is capable of making the transition into a pathogen following its ingestion by susceptible humans or animals. Recent studies suggest that L. monocytogenes mediates its saprophyte-to-cytosolic-parasite transition through the careful modulation of the activity of a virulence regulatory protein known as PrfA, using a range of environmental cues that include available carbon sources. In this Progress article we… CONTINUE READING
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Constitutive activation of the PrfA regulon enhances the potency of vaccines based on liveattenuated and killed but metabolically active Listeria monocytogenes strains

  • P Lauer
  • Infect. Immun
  • 2008
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