Listening to Prozac but Hearing Placebo: A Meta-Analysis of Antidepressant Medication

  title={Listening to Prozac but Hearing Placebo: A Meta-Analysis of Antidepressant Medication},
  author={I. Kirsch and G. Sapirstein},
  journal={Prevention & Treatment},
  • I. Kirsch, G. Sapirstein
  • Published 1998
  • Medicine
  • Prevention & Treatment
  • Key MethodMean effect sizes for changes in depression were calculated for 2,318 patients who had been randomly assigned to either antidepressant medication or placebo in 19 double-blind clinical trials. As a proportion of the drug response, the placebo response was constant across different types of medication (75%), and the correlation between placebo effect and drug effect was .90. These data indicate that virtually all of the variation in drug effect size was due to the placebo characteristics of the…Expand Abstract
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    Meta-analysis of the placebo response in antidepressant trials.
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    Antidepressants and the placebo response.
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    Mechanisms of the Placebo Effect and of Conditioning
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    Publications referenced by this paper.
    A Meta‐Analysis of Fluoxetine Outcome in the Treatment of Depression
    • 104
    A meta-analysis of antidepressant outcome under "blinder" conditions.
    • 81
    Antidepressant Treatment of Depression: A Metaanalysis
    • 116
    • Highly Influential
    • PDF
    Paroxetine versus placebo: a double-blind comparison in depressed patients.
    • 46
    • Highly Influential
    A meta-analysis of the efficacy of cognitive therapy for depression.
    • 768
    Review of placebo-controlled trials with bupropion.
    • 52
    • Highly Influential
    Sertraline in the prevention of depression.
    • 230