Lissencephaly-1 is a context-dependent regulator of the human dynein complex

  title={Lissencephaly-1 is a context-dependent regulator of the human dynein complex},
  author={Janina Baumbach and Andal S. Murthy and Mark A McClintock and Carly I. Dix and Ruta Zalyte and Ha Thi Hoang and Simon L Bullock},
The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we elucidate in vitro the roles of dynactin, end-binding protein-1 (EB1) and Lissencephaly-1 (LIS1) in the interaction of end tracking and minus end-directed human dynein complexes with these sites. LIS1 promotes dynactin-dependent tracking of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 39 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 11 extracted citations


Publications referenced by this paper.
Showing 1-10 of 122 references

Similar Papers

Loading similar papers…