Lisdexamfetamine and immediate release d-amfetamine – Differences in pharmacokinetic/pharmacodynamic relationships revealed by striatal microdialysis in freely-moving rats with simultaneous determination of plasma drug concentrations and locomotor activity
@article{Rowley2012LisdexamfetamineAI, title={Lisdexamfetamine and immediate release d-amfetamine – Differences in pharmacokinetic/pharmacodynamic relationships revealed by striatal microdialysis in freely-moving rats with simultaneous determination of plasma drug concentrations and locomotor activity}, author={Helen L. Rowley and Rajiv S. Kulkarni and J Gosden and Richard J Brammer and David J. Heal}, journal={Neuropharmacology}, year={2012}, volume={63}, pages={1064-1074} }
51 Citations
Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects
- Biology, MedicineFront. Pharmacol.
- 2017
The pharmacokinetics and pharmacodynamics of lisdexamfetamine are similar to D-amphetamine administered 1h later, and are likely associated with a similar risk of oral abuse as D- methamphetamine.
Differences in the neurochemical and behavioural profiles of lisdexamfetamine methylphenidate and modafinil revealed by simultaneous dual-probe microdialysis and locomotor activity measurements in freely-moving rats
- Biology, PsychologyJournal of psychopharmacology
- 2014
The neurochemical and behavioural profiles of lisdexamfetamine, methylphenidate and modafinil were compared by dual-probe microdialysis in the prefrontal cortex (PFC) and striatum of conscious rats with simultaneous locomotor activity measurement, showing larger and more sustained effects on catecholaminergic neurotransmission.
Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: A novel d-amphetamine pro-drug
- BiologyNeuropharmacology
- 2014
A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to
d
-amfetamine, methylphenidate and modafinil
- Biology, MedicineNeuropharmacology
- 2013
Effects of lisdexamfetamine on plasma steroid concentrations compared with d-amphetamine in healthy subjects: A randomized, double-blind, placebo-controlled study
- Biology, MedicineThe Journal of Steroid Biochemistry and Molecular Biology
- 2019
Effects of Lisdexamfetamine, a Prodrug of D-Amphetamine, on Locomotion, Spatial Cognitive Processing and Neurochemical Profiles in Rats: A Comparison With Immediate-Release Amphetamine
- Biology, PsychologyFrontiers in Psychiatry
- 2022
Results suggest that lisdexamfetamine was more effective than d-amphetamine in improving spatial cognitive performance, which was attributed to the steady and lasting dopamine release pattern within the mPFC.
Lisdexamfetamine and amphetamine pharmacokinetics in oral fluid, plasma, and urine after controlled oral administration of lisdexamfetamine
- Biology, MedicineBiopharmaceutics & drug disposition
- 2020
There was a correlation between oral fluid and plasma d‐AMPH concentrations and between parent to metabolite concentration ratios over time in plasma as well as in oral fluid.
Lisdexamfetamine Dimesylate: Prodrug Delivery, Amphetamine Exposure and Duration of Efficacy
- Biology, MedicineClinical Drug Investigation
- 2016
Drug-liking scores for LDX are lower than for an equivalent dose of IR d-amphetamine, which may result from the reduced euphorigenic potential associated with its pharmacokinetic profile.
Role of d-amphetamine and d-methamphetamine as active metabolites of benzphetamine: Evidence from drug discrimination and pharmacokinetic studies in male rhesus monkeys
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 2017
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At an equivalent amount of amphetamine base taken orally, LDX 100 mg had attenuated responses on measures of abuse liability compared with immediate-release d-amphetamine 40 mg, and diethylpropion hydrochloride, a Schedule IV amphetamine-like stimulant, on abuse-related liking scores.