Lis1 restricts the conformational changes in cytoplasmic dynein on microtubules.

@article{Toba2015Lis1RT,
  title={Lis1 restricts the conformational changes in cytoplasmic dynein on microtubules.},
  author={S. Toba and Kotaro Koyasako and T. Yasunaga and S. Hirotsune},
  journal={Microscopy},
  year={2015},
  volume={64 6},
  pages={
          419-27
        }
}
  • S. Toba, Kotaro Koyasako, +1 author S. Hirotsune
  • Published 2015
  • Chemistry, Medicine
  • Microscopy
  • Cytoplasmic dynein is a microtubule-based motor protein that transports intracellular cargo and performs various functions during cell division. We previously reported that Lis1 suppressed dynein motility on microtubules in an idling state. Recently, a model showed that Lis1 prevents the ATPase domain of dynein from transmitting a detachment signal to its microtubule-binding domain. However, conformational information on dynein is limited. We used electron microscopy to investigate the… CONTINUE READING
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