Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization.

@article{Sipe2013Lis1MP,
  title={Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization.},
  author={Conor W Sipe and Lixia Liu and Jianyi Lee and Cynthia Mary Grimsley-Myers and Xiaowei Lu},
  journal={Development},
  year={2013},
  volume={140 8},
  pages={1785-95}
}
The V-shaped hair bundles atop auditory hair cells and their uniform orientation are manifestations of epithelial planar cell polarity (PCP) required for proper perception of sound. PCP is regulated at the tissue level by a conserved core Wnt/PCP pathway. However, the hair cell-intrinsic polarity machinery is poorly understood. Recent findings implicate hair cell microtubules in planar polarization of hair cells. To elucidate the microtubule-mediated polarity pathway, we analyzed Lis1 function… CONTINUE READING

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