Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca(2+)-XO-ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways.

Abstract

Microvascular endothelial cells (CMECs) oxidative damage resulting from hypoxia/reoxygenation (H/R) injury is responsible for microcirculation perfusion disturbances and the progression of cardiac dysfunction. However, few strategies are available to reverse such pathologies. Here, we studied the effects and mechanisms of liraglutide on CEMCs oxidative… (More)
DOI: 10.1016/j.freeradbiomed.2016.03.035

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Cite this paper

@article{Zhang2016LiraglutidePC, title={Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca(2+)-XO-ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways.}, author={Ying Zhang and Hao David Zhou and Wenbo Wu and Chen Shi and Shunying Hu and Tong Sin Yin and Qiang Ma and Tianwen Han and Yingqian Zhang and Feng Tian and Yundai Chen}, journal={Free radical biology & medicine}, year={2016}, volume={95}, pages={278-92} }