Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)

@inproceedings{Marre2009LiraglutideAO,
  title={Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)},
  author={Michel Marre and Julia Shaw and Michael Br{\"a}ndle and Wan Mohamad Wan Bebakar and Nor Azmi Kamaruddin and Jorma Strand and Milan Zdravkovic and Tu Duyen Le Thi and Stephen Colagiuri},
  booktitle={Diabetic medicine : a journal of the British Diabetic Association},
  year={2009}
}
AIM To compare the effects of combining liraglutide (0.6, 1.2 or 1.8 mg/day) or rosiglitazone 4 mg/day (all n >or= 228) or placebo (n = 114) with glimepiride (2-4 mg/day) on glycaemic control, body weight and safety in Type 2 diabetes. METHODS In total, 1041 adults (mean +/- sd), age 56 +/- 10 years, weight 82 +/- 17 kg and glycated haemoglobin (HbA(1c)) 8.4 +/- 1.0% at 116 sites in 21 countries were stratified based on previous oral glucose-lowering mono : combination therapies (30 : 70%) to… CONTINUE READING
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