Liquid secretion inhibitors reduce mucociliary transport in glandular airways.

  title={Liquid secretion inhibitors reduce mucociliary transport in glandular airways.},
  author={Stephen T Ballard and Laura Trout and Anil Mehta and Sarah K. Inglis},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={283 2},
Because of its possible importance in cystic fibrosis (CF) pulmonary pathogenesis, the effect of anion and liquid secretion inhibitors on airway mucociliary transport was examined. When excised porcine tracheas were treated with ACh to induce gland liquid secretion, the rate of mucociliary transport was increased nearly threefold from 2.5 +/- 0.5 to 6.8 +/- 0.8 mm/min. Pretreatment with both bumetanide and dimethylamiloride (DMA), to respectively inhibit Cl(-) and HCO secretion, significantly… CONTINUE READING


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Contribution of chloride and bicarbonate transport to acetylcholineinduced liquid secretion in porcine bronchial epithelium

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