Liquid secretion inhibitors reduce mucociliary transport in glandular airways.

@article{Ballard2002LiquidSI,
  title={Liquid secretion inhibitors reduce mucociliary transport in glandular airways.},
  author={S. Ballard and L. Trout and Anil C. Mehta and S. Inglis},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={283 2},
  pages={
          L329-35
        }
}
  • S. Ballard, L. Trout, +1 author S. Inglis
  • Published 2002
  • Medicine, Chemistry
  • American journal of physiology. Lung cellular and molecular physiology
  • Because of its possible importance in cystic fibrosis (CF) pulmonary pathogenesis, the effect of anion and liquid secretion inhibitors on airway mucociliary transport was examined. When excised porcine tracheas were treated with ACh to induce gland liquid secretion, the rate of mucociliary transport was increased nearly threefold from 2.5 +/- 0.5 to 6.8 +/- 0.8 mm/min. Pretreatment with both bumetanide and dimethylamiloride (DMA), to respectively inhibit Cl(-) and HCO secretion, significantly… CONTINUE READING
    Mucociliary transport in porcine trachea: differential effects of inhibiting chloride and bicarbonate secretion.
    38

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