Liquid-phase combinatorial synthesis.

  title={Liquid-phase combinatorial synthesis.},
  author={Hongna Han and Megan M Wolfe and S. Brenner and Kim D Janda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 14},
A concept termed liquid-phase combinatorial synthesis (LPCS) is described. The central feature of this methodology is that it combines the advantages that classic organic synthesis in solution offers with those that solid-phase synthesis can provide, through the application of a linear homogeneous polymer. To validate this concept two libraries were prepared, one of peptide and the second of nonpeptide origin. The peptide-based library was synthesized by a recursive deconvolution strategy [Erb… CONTINUE READING

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