Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex.

@article{Melckebeke2008LiquidcrystalNS,
  title={Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex.},
  author={H{\'e}l{\`e}ne Van Melckebeke and Matthew Devany and Carmelo Di Primo and François Beaurain and Jean-Jacques Toulm{\'e} and David L Bryce and Jerome Boisbouvier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 27},
  pages={
          9210-5
        }
}
Transactivation-response element (TAR) is a stable stem-loop structure of HIV RNA, which plays a crucial role during the life cycle of the virus. The apical loop of TAR acts as a binding site for essential cellular cofactors required for the replication of HIV. High-affinity aptamers directed against the apical loop of TAR have been identified by the SELEX approach. The RNA aptamers with the highest affinity for TAR fold as hairpins and form kissing complexes with the targeted RNA through loop… CONTINUE READING

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