Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract.

@article{Prasain2009LiquidCT,
  title={Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract.},
  author={J K Prasain and Ning Peng and Yanying Dai and Ray H. Moore and Alireza Arabshahi and Landon Wilson and Stephen Barnes and J Michael Wyss and Helen S. Kim and Ray L. Watts},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2009},
  volume={16 2-3},
  pages={233-43}
}
Proanthocyanidin rich plant extracts derived from grape seed extract (GSE), hawthorn and cranberry are on markets for their preventive effects against cardiovascular diseases and uroinfections in woman. However, the importance of these health beneficial effects of these botanicals remains elusive due to incomplete understanding of uptake, metabolism and bioavailability of proanthocyanidins in vivo. In the present study rats were given GSE orally (300 mg/kg, twice a day) and blood and urine were… CONTINUE READING