Liquid chromatography-tandem mass spectrometry-based plasma metabonomics delineate the effect of metabolites' stability on reliability of potential biomarkers.

@article{Yang2013LiquidCM,
  title={Liquid chromatography-tandem mass spectrometry-based plasma metabonomics delineate the effect of metabolites' stability on reliability of potential biomarkers.},
  author={Wei Yang and Yanhua Chen and Cong Xi and Ruiping Zhang and Yongmei Song and Qimin Zhan and Xiaofeng Bi and Zeper Abliz},
  journal={Analytical chemistry},
  year={2013},
  volume={85 5},
  pages={2606-10}
}
Metabonomics is an important platform for investigating the metabolites of integrated living systems and their dynamic responses to changes caused by both endogenous and exogenous factors. A metabonomics strategy based on liquid chromatography-mass spectrometry/mass spectrometry in both positive and negative ion modes was applied to investigate the short-term and long-term stability of metabolites in plasma. Principal components analysis and ten types of identified metabolites were used to… CONTINUE READING

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