• DOI:10.1194/jlr.M600497-JLR200
Corpus ID: 8544887

Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterolss⃞ Published, JLR Papers in Press, January 24, 2007.

@article{Karu2007LiquidCS,
  title={Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterolss⃞ Published, JLR Papers in Press, January 24, 2007.},
  author={K. Karu and M. Hornshaw and G. Woffendin and K. Bodin and M. H{\'a}mberg and G. Alv{\'e}lius and J. Sjövall and J. Turton and Yuqin Wang and W. Griffiths},
  journal={Journal of Lipid Research},
  year={2007},
  volume={48},
  pages={976 - 987}
}

K. Karu, M. Hornshaw, +7 authors W. Griffiths

Published 2007

Chemistry, Medicine

Journal of Lipid Research

In humans, the brain accounts for about 20% of the body's free cholesterol, most of which is synthesized de novo in brain. To maintain cholesterol balance throughout life, cholesterol becomes metabolized to 24S-hydroxycholesterol, principally in neurons. In mouse, rat, and probably human, metabolism to 24S-hydroxycholesterol accounts for about 50% of cholesterol turnover; however, the route by which the remainder is turned over has yet to be elucidated. Here, we describe a novel liquid… CONTINUE READING

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