Liquid chromatography--electrospray ionization mass spectrometric detection of an ethenodeoxyguanosine adduct and its hemiaminal precursors in DNA reacted with alpha-acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal.

Abstract

N-Nitrosopiperidine, a carcinogenic cyclic nitrosamine that occurs in the diet and may be formed endogenously, is believed to be metabolically activated by alpha-hydroxylation. The DNA reactive compounds that could be formed in this process have been studied using alpha-acetoxy-N-nitrosopiperidine as a model. Previous studies have shown that 4-oxo-2… (More)

Topics

  • Presentations referencing similar topics