Liquid chromatographic enantioseparation of three beta-adrenolytics using new derivatizing reagents synthesized from (S)-ketoprofen and confirmation of configuration of diastereomers.

@article{Alwera2016LiquidCE,
  title={Liquid chromatographic enantioseparation of three beta-adrenolytics using new derivatizing reagents synthesized from (S)-ketoprofen and confirmation of configuration of diastereomers.},
  author={Shiv Alwera and R. Bhushan},
  journal={Biomedical chromatography : BMC},
  year={2016},
  volume={30 11},
  pages={
          1772-1781
        }
}
  • Shiv Alwera, R. Bhushan
  • Published 2016
  • Chemistry, Medicine
  • Biomedical chromatography : BMC
    • Diastereomers of racemic β-adrenolytic drugs [namely (RS)-propranolol, (RS)-metoprolol and (RS)-atenolol] were synthesized under microwave irradiation with (S)-ketoprofen based chiral derivatization reagents (CDRs) newly synthesized for this purpose. (S)-Ketoprofen was chosen for its high molar absorptivity (εo  ~ 40,000) and its availability as a pure (S)-enantiomer. Its -COOH group was activated with N-hydroxysuccinimide and N-hydroxybenzotriazole; these were easily introduced and also acted… CONTINUE READING
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    9 Citations
    Background Citations
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    Methods Citations
    1
    9 Citations
    Citation Type

    Citation Type

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    Methods and approaches for determination and enantioseparation of (RS)-propranolol.
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