Liquid chromatographic enantioseparation of beta-blocking agents with (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propyl isothiocyanate as chiral derivatizing agent.

@article{Pter2001LiquidCE,
  title={Liquid chromatographic enantioseparation of beta-blocking agents with (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propyl isothiocyanate as chiral derivatizing agent.},
  author={M. P{\'e}ter and {\'A}. Gy{\'e}resi and F. F{\"u}l{\"o}p},
  journal={Journal of chromatography. A},
  year={2001},
  volume={910 2},
  pages={
          247-53
        }
}
  • M. Péter, Á. Gyéresi, F. Fülöp
  • Published 2001
  • Chemistry, Medicine
  • Journal of chromatography. A
  • The applicability of (1R,2R)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propyl isothiocyanate [(R,R)-DANI] as a recently developed chiral derivatizing agent for the enantioseparation of a series of beta-blockers is described. The thiourea diastereomers formed were analyzed by reversed-phase high-performance liquid chromatography, mixtures of water and methanol or acetonitrile being used for elution. Conditions of derivatizations (temperature, reagent excess and reaction time) were optimized, and the… CONTINUE READING
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