Liquid-chromatographic assay of cimetidine in plasma and gastric fluid.

  title={Liquid-chromatographic assay of cimetidine in plasma and gastric fluid.},
  author={M Abdel-Rahim and David Ezra and Chris Peck and Josef Lazar},
  journal={Clinical chemistry},
  volume={31 4},
In this micro-scale method for liquid-chromatographic measurement of cimetidine in 250-microL volumes of plasma or gastric fluid, a combination of organic- and aqueous-phase extractions, and protonation of the internal standard and cimetidine, enabled us to detect 2.0 ng of cimetidine on the column. We also used a radial compression module, which reduced the retention times for cimetidine and the internal standard to only 2.78 and 2.00 min. The speed and sensitivity of this method facilitates… CONTINUE READING

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