Liquid chromatographic analysis of thiopental in blood and tissues.

@article{Levine1983LiquidCA,
  title={Liquid chromatographic analysis of thiopental in blood and tissues.},
  author={B. Levine and R. Blanke and J. Valentour},
  journal={Journal of analytical toxicology},
  year={1983},
  volume={7 4},
  pages={
          207-8
        }
}
A liquid chromatographic method for the quantitation of thiopental in blood and tissues is presented. Quantitation in blood utilizes a single step dichloromethane extraction at pH 5.5. After mixing and centrifugation, the organic layer is evaporated to dryness at 40 degrees C and the residue reconstituted with methanol. Tissue extraction includes an alkaline clean-up step followed by re-extraction with dichloromethane after acidification. Either of two 10 mu columns can be used: a C8 or a C18… Expand
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