Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study.

@article{Shao2006LiquidCS,
  title={Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study.},
  author={Feng Shao and Guang-ji Wang and Jingjng Sun and Haitang Xie and Hao Li and Yan Liang and Rong Zhang and Xiaoyan Zhu},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2006},
  volume={41 2},
  pages={
          341-6
        }
}
A rapid and sensitive method for the determination of triptolide in dog plasma was developed and validated, using high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry (LC/APCI/MS). Sample preparation consisted of liquid-liquid extraction with ethyl acetate from dog plasma. The analytes and internal standard prednisolone were well separated on a Zorbax Extend-C18 analytical column. Detection was performed on a triple quadrupole mass spectrometer using… CONTINUE READING

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